Enantioselective Total Synthesis of (+)-Lysergol: A Formal <i>anti</i>‑Carbopalladation/Heck Cascade as the Key Step
收藏NIAID Data Ecosystem2026-03-10 收录
数据链接：
官方服务：
资源简介：
The enantioselective synthesis of (+)-lysergol was completed in 12 steps and an overall yield of 13% starting from a known literature precursor. The key step relies on a domino reaction containing a formal anti-carbopalladation, which is terminated by a β-silyl-directed Heck reaction. During this transformation, the two six-membered rings of the ergot scaffold are formed in a completely stereospecific manner.
创建时间：
2017-03-30
