HCS mutations located in known CTLa.

aIn the examined regions, 44 Gag and 17 Env CTL epitopes have been optimally defined [33], among which 4 Gag and 3 Env epitopes are known to be restricted by HLA alleles of PIC87014 (A*0201, A*2501, B*1801, B*5101, Cw*0102, and Cw*1203) and all 7 were recognized by the subject [20]. PIC87014 also recognized 2 additional Env-gp120 epitopes (NW9, Env 88–96 and TL9, Env 341–349, Figure 2).bFRDYVDRFYK (FK10, Gag 293–302) is B*1801 restricted. YCAPAGFAIL (YL10, Env 271–226) is Cw*0102 restricted. The underlined letters indicate the location of the HCS mutations.