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Treatment of Wnt-addicted pancreatic cancer with combination of PORCN and trametinib

NIAID Data Ecosystem2026-05-01 收录

胰腺癌联合用药

Wnt通路靶向治疗

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP261748 数据链接链接失效反馈

官方服务：

资源简介：

Treatment of HPAF-II orthotopic xenografts with ETC-159 (a PORCN inhibitor) in combination with trametinib (an ERK inhibitor)

应用场景：

创建时间：

2023-03-30

胰腺癌联合用药

抗肿瘤药物疗效评估

Either metformin or liraglutide has been reported to have anti-tumor effects on pancreatic cancer cells. However, it is not clear whether their combined treatment has additive or synergistic anti-tumo

NIAID Data Ecosystem10

Supplementary file 2_Synergistic anticancer effects of camptothecin and sotorasib in KRAS-mutated pancreatic ductal adenocarcinoma.xlsx

胰腺癌联合用药

KRAS突变耐药性研究

BackgroundSotorasib (AMG510) is a first-in-class irreversible, covalent, and selective KRAS G12C inhibitor. However, in patients, acquired clinical resistance was observed within 1 year of its FDA app

NIAID Data Ecosystem00

Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model

Wnt通路靶向治疗

癌症计算模型

BackgroundDespite considerable investigational efforts, no method to overcome the pathogenesis caused by loss of function (LoF) mutations in tumor suppressor genes has been successfully translated to

Figshare2017-07-15 更新00

DataSheet_1_Beyond TNBC: Repositioning of Clofazimine Against a Broad Range of Wnt-Dependent Cancers.docx

Wnt通路靶向治疗

药物重定位抗癌

Wnt signaling plays key roles in oncogenic transformation and progression in a number of cancer types, including tumors in the breast, colon, ovaries, liver, and other tissues. Despite this importance

NIAID Data Ecosystem10

Supplementary Table S2 from Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor

肿瘤药物筛选

胰腺癌联合用药

Single agent AUC

Figshare2017-06-01 更新00