EFFICACY AND SAFETY OF MIRABEGRON PLUS VITAMIN D3 VS MIRABEGRON ALONE IN THE TREATMENT OF ADULT PATIENTS OF OVERACTIVE BLADDER: A RANDOMIZED CONTROLLED TRIAL

Introduction: Overactive bladder (OAB) is a syndrome of complex etiology affecting millions of patients worldwide. Both pharmacological and non-pharmacological treatment options have been tried for resolution of its symptoms with limited option in pharmacotherapy of OAB. β3 receptor agonists like mirabegron are now mainstay of treatment.

Material and methods: This open labelled, randomized controlled study was conducted with 99 patients divided into 3 groups based on their vitamin D levels and evaluation of OAB symptoms was done at baseline, 4 weeks, 8 weeks and 12 weeks using urgency severity score (USS), overactive bladder symptoms severity score (OABSS) and three days voiding diary.

Result: At each follow-up visit severity of symptoms reduced gradually and difference was statistically significant in all the parameters. There was significant difference between group B and group C at the end of study. 

Conclusion: This study concluded that severity of the symptoms was higher in Vitamin D insufficient patients and reduction in symptoms was higher in group C suggesting that vitamin D supplementation may be helpful in reducing the symptoms of OAB.