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SUPERSEDED - Production system drivers of antibiotic resistance at the human-animal interface in Uganda

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DataCite Commons2024-08-13 更新2025-04-17 收录
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https://datashare.ed.ac.uk/handle/10283/4833
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## This item has been replaced by the one which can be found at [https://doi.org/10.7488/ds/7792] ##' This dataset and code are part of supplementary data for a manuscript Muwonge, A., Kakooza, T., Johnson, P.C.D., Kisuule, L., Kimaanga, M., Kankya, C., de Clare Bronsvoort, B.M., Lembo, T., "Production system drivers of antibiotic resistance at the human-animal interface in Uganda", The Lancet Planetary Health (in submission). They explore the role of livestock production systems in the epidemiology of antibacterial resistance (ABR) in sympatric human and livestock populations, which is poorly understood. Here, they examine ABR at the farmer-pig interface of Uganda, where the pig sector is rapidly growing, to quantify rates of resistance, understand associated human- and livestock-related factors, and investigate cross-species transmission. The motivation of this is to improve our understanding of the role of livestock production systems in the emergence and transmission of AMR, this paper uses phenotypic resistance profile from sentinel bacteria E.coli and Klebsiella, recovered from a faecal sample collected from farmers and their pigs across a one-year longitudinal study. This is mapped to AMR gene carriage of four selected genes measured using QPCR. Using the Metadata, they examine drivers of resistance in this setting, and also use the prevalence and sharing of MDR profiles to infer transmission.
提供机构:
University of Edinburgh. The Roslin Institute
创建时间:
2023-03-27
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