Metabolic profiles of C57BL/6J mice treated with PBS and recombinant pika leptin under different temperatures.

aAfter acclimation at 23±1°C for 7 days, the mice were treated at 23±1°C for 7 days,named as WL (pika leptin-treated) and WP (PBS-treated), respectively.bAfter cold acclimation (5±1°C) for 28 days, the mice were treated for 7 days at 5±1°C, named as CL(pika leptin-treated) and CP(PBS-treated), respectively.*Significant difference between PBS and pika leptin groups at day 7 at 22±2°C.++Significant difference between PBS and pika leptin groups at day 7 of treatment at 5±1°C after chronic cold acclimation for 28 days.