The identification of genes altered by RORα in progression of non-alcoholic steatohepatitis (NASH). Mus musculus

Purpose: To identify the target genes of RORα associated with development of NASH Methods: RNA isolation for sequencing analysis from liver tissues of High fat diet (HFD)-fed RORα-LKO and RORα f/f mice and mRNA-sequencing Conclusion: When calcuated by dividing the normalized read count of HFD-fed RORα-LKO by that of RORαf/f,.there are 8505 genes altered by RORα deletion (cut-off, 0.8-fold, 1.5-fold). Overall design: mRNA profiles of HFD-fed control (RORα f/f) and RORα liver-specific KO (LKO) mice