Data for: Nanostructured lipid carriers containing ondansetron hydrochloride by cold high-pressure homogenization method: preparation, characterization, and pharmacokinetic evaluation

The data describe the preparation, optimization, characterization, and evaluation of nanostructured lipid carriers (NLCs) loaded with ondansetron hydrochloride (OSH), a water-soluble drug. A modified cold high-pressure homogenization method was used, and the pH-dependent solubility of OSH was exploited to obtain NLCs with the enhanced entrapment efficiency (EE). The optimized formulation exhibited the sustained-release characteristic of the drug in vitro. After single subcutaneous injection in rats, the optimized OSH-loaded NLCs could prolong the drug release until 96 h with an extended mean resident time and enhanced systemic exposure compared to the OSH solution.本数据集涵盖了水溶性药物盐酸昂丹司琼（ondansetron hydrochloride，OSH）负载纳米结构脂质载体（nanostructured lipid carriers，NLCs）的制备、优化、表征与评价全流程。研究采用改良冷高压均质法，结合OSH的pH依赖性溶解度特性，以制备得到包封率（entrapment efficiency，EE）显著提升的NLCs。优化后的制剂在体外表现出明确的药物缓释特性。对大鼠实施单次皮下注射后，与OSH溶液组相比，优化后的OSH负载NLCs可将药物释放时长延长至96小时，平均驻留时间显著延长，同时全身暴露量亦得到有效提升。