Whole genome sequencing for molecular characterization of carbapenem resistant Klebsiella pneumoniae isolated from a tertiary care hospital of Bihar.

The presence of carbapenem genes was associated with a sequence encoding for resistance to carbapenems located on the chromosome of KP, identifying the genome of KP as a possible reservoir of MDR. This finding may help in future clinical application of real-time WGS applications to transform in the investigation and management of challenging nosocomial pathogens by overcoming the resolution limitations of analyzing bacterial genomes. Identification of genetic variations will improve our knowledge on future medicines to control MDR and its evolution.