Morphological and expression features of ductal pancreatic adenocarcinoma.

Pancreatic cancer is one of the most unfavorable malignancies. Approximately 20 % of patients with pancreatic
cancer have resectable disease at the time of diagnosis, however the prognosis of the disease in these patients
remains poor, and the overall 5-year survival rate is only 5 %. The evaluation of morphological features, as well
as features of the expression of markers that determine the invasive potential of such neoplasms, can serve
in the future as a fundamental basis in solving problems concerning prognostic factors in pancreatic cancer.
the purpose of the study was to evaluate morphological and immunohistochemical features of pancreatic
ductal adenocarcinoma. Material and methods. The study included 84 patients with stage T1–4N0–2M0–1
pancreatic cancer. The age range was from 37 to 83 years. Surgery was the main treatment option. Morphological examination of surgical specimens showed that the tumor histotype corresponded to pancreatic ductal
adenocarcinoma. The preparation of histological specimens and immunohistochemical staining were carried out
according to standard procedures. results and conclusion. This study allowed us to determine the features of
tumor morphology, as well as the features of expression of markers associated with more pronounced invasive
properties of the tumor. The results of this study may be of interest in terms of their further comparison with the
parameters of various forms of progression in pancreatic cancer.