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Single-molecule long-read sequencing reveals the chromatin basis of gene expression

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NIAID Data Ecosystem2026-05-26 收录
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Chromatin status is highly relevant to gene transcription. We present a new experimental approach MeSMLR-seq (methyltransferase treatment followed by single-molecule long-read sequencing) for long-range mapping of chromatin accessibility and nucleosomes at single DNA molecules, and thus achieve comprehensive-coverage characterization of the corresponding heterogeneity.

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2019-05-30
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