Single-cell RNA sequencing of human salivary gland derived mesenchymal stromal cells under cytokine treatment conditions

Mesenchymal stromal cells (MSCs) reside in tissue stroma and are
associated with potent immunomodulatory and trophic properties.
Furthermore, the immunomodulatory properties of MSCs are traditionally
optimized with cytokine stimulation such as with IFNγ or both IFNγ and
TNFα. The effect of these cytokines on MSC(SG) are unknown. We report the
study of labial salivary gland-derived MSCs (MSC[SG]) as a potential MSC
source with beneficial immunomodulatory and trophic properties. We studied
MSC(SG) after cytokine pre-licensing with vehicle,  IFNγ, TNFα,
or both IFNγ and TNFα (dual treatment).