OvirusTdb: A database of oncolytic viruses for the advancement of therapeutics in cancer

OvirusTdb: Database of Oncolytic Viruses for Cancer Therapeutics Overview OvirusTdb is a manually curated database of experimentally validated oncolytic viruses (OVs) developed for cancer therapeutics and immunotherapy research. The database provides detailed information on: Oncolytic viruses Viral genomic modifications Cancer specificity Immune activation Apoptosis induction Combination therapies Experimental validation Web Server: https://webs.iiitd.edu.in/raghava/ovirustdb/ Research Paper Title: OvirusTdb: A database of oncolytic viruses for the advancement of therapeutics in cancer Authors:Anjali Lathwal, Rajesh Kumar, and Gajendra P. S. Raghava Journal: Virology (2020) DOI: https://doi.org/10.1016/j.virol.2020.05.016 https://github.com/Piyushh1104/OvirusTdb.git Background Oncolytic viruses (OVs) selectively infect and destroy cancer cells while sparing normal cells. They also stimulate anti-tumor immune responses through: Tumor-associated antigen release Cytokine secretion T-cell activation Dendritic cell activation Oncolytic virotherapy is an emerging strategy in: Cancer immunotherapy Precision oncology Combination therapy Database Statistics OvirusTdb contains: 5927 total records 5456 research article records 471 patent records Viral Information 24 viral species 9 DNA viruses 15 RNA viruses Viral Strains 300 genetically modified viral strains 15 wild-type viral strains Cancer Coverage 124 cancer types 427 cancer cell lines Experimental Coverage 30 assay types 22 model organisms Important Findings Immune Activation 1506 records show immune activation Apoptosis Induction 3243 records indicate apoptosis induction Combination Therapy 1047 records contain chemo-virotherapy information Viral Species Included The database includes: Adenovirus Herpes Simplex Virus (HSV) Vaccinia Virus Reovirus Measles Virus Newcastle Disease Virus Vesicular Stomatitis Virus Alphavirus Parvovirus and other experimentally tested oncolytic viruses. Genomic Modifications The database stores information on: Gene insertions Gene deletions Immune gene engineering Tumor targeting modifications Example Modifications IL-2 insertion TRAIL insertion EGFP insertion ICP34.5 deletion E1A deletion E1B deletion Chemo-Virotherapy Information Combination therapies include drugs such as: Paclitaxel Cisplatin Gemcitabine Vincristine Doxorubicin 5-Fluorouracil Temozolomide