Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z100643660 (A71EV2A-x0451)

Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z100643660 (A71EV2A-x0451) Descriptor: DIMETHYL SULFOXIDE, N,1-dimethyl-1H-indole-3-carboxamide, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

针对柯萨奇病毒A16（Coxsackievirus A16）G-10株2A蛋白酶的晶体片段筛选数据集集体提交——结合配体Z100643660（A71EV2A-x0451）的柯萨奇病毒A16（G-10）2A蛋白酶晶体结构。配体描述：二甲基亚砜（DIMETHYL SULFOXIDE）、N,1-二甲基-1H-吲哚-3-甲酰胺、2A蛋白酶（Protease 2A）等。作者：Lithgo, R.M.、Fairhead, M.、Koekemoer, L.、Balcomb, B.H.、Capkin, E.、Chandran, A.V.、Golding, M.、Godoy, A.S.、Aschenbrenner, J.C.、Marples, P.G.、Ni, X.、Thompson, W.、Tomlinson, C.W.E.、Wild, C.、Winokan, M.、Xavier, M.-A.E.、Fearon, D.、von Delft, F.。沉积日期：2024-04-04；发布日期：2024-04-24；最后修改日期：2024-10-16。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.5 Å）。引用文献：《柯萨奇病毒A16 2A蛋白酶晶体片段筛选发现广谱抗肠病毒研发新机遇》，BioRxiv，2024年