Human Ornithine Aminotransferase cocrystallized with its inhibitor, (3S,4R)-3-amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylate

Human Ornithine Aminotransferase cocrystallized with its inhibitor, (3S,4R)-3-amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylate Descriptor: (1S,3R,4S)-3-formyl-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopentane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial Authors: Butrin, A, Zhu, W, Silverman, R, Liu, D. Deposit date: 2022-01-05 Release date: 2022-04-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. J.Am.Chem.Soc., 144, 2022

人鸟氨酸氨基转移酶（Ornithine aminotransferase）与其抑制剂(3S,4R)-3-氨基-4-(二氟甲基)环戊-1-烯-1-羧酸的共晶复合物。数据集描述：(1S,3R,4S)-3-甲酰基-4-[({3-羟基-2-甲基-5-[(膦酰氧基)甲基]吡啶-4-基}甲基)氨基]环戊烷-1-羧酸、线粒体鸟氨酸氨基转移酶。作者：Butrin, A、Zhu, W、Silverman, R、Liu, D。提交日期：2022-01-05，发布日期：2022-04-06，最后修改日期：2023-10-18。实验方法：X射线衍射（1.91 Å）。引用文献：《理性设计、合成及(3S,4R)-3-氨基-4-(二氟甲基)环戊-1-烯-1-羧酸的作用机制：采用二次去质子化策略实现人鸟氨酸氨基转移酶相较于γ-氨基丁酸（GABA）氨基转移酶的选择性》，《美国化学会志》（J.Am.Chem.Soc.），2022年，第144卷。