Epigenetic alterations are one of the key hallmarks of aging. Emerging evidence in model organisms, senescent cell cultures and limitedly, murine, and human tissue samples suggest local effects impact
DNA methylation plays an important role in development of disease and the process of aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of white blood cells from a
In this study, we report the effects of graded levels of CR and IF initiated during adulthood (at 6 months of age) on the health and lifespan of a large cohort of DO mice. We utilized a unique cohort
