A zipped file containing a program in C named S1_File.c for estimating the set of combined parameters , or initial conditions and parameters from the dataset of the first one and half cycles of each patient using the prior distribution obtained from the set of the past patients.

The input file should be the CSV file format as in ones at http://www.nicholasbruchovsky.com/clinicalResaerch.html, where the columns should be, from the left, the patient number (not used), the date (not used), the amount of prescribed CPA (not used), the amount of prescribed LEU (not used), the PSA level, the testosterone level (not used), the number of cycle, whether the hormone therapy is on (1) or off (0), the accumulated number of days, and the accumulated number of days starting from a different day (not used). Each line corresponds to a day where either the PSA and/or testosterone level was measured or the treatment option was changed. The output is generated in a file called fitted_params8a2c2b2.dat. The output is a single column containing the estimated combined parameters . The values from the first line show x1(0), x2(0), x3(0), , , , , , , , , , and . In the last line, the program outputs the value for the cost function. In between, you find eight 0s, which may be used for the future developments.
(ZIP)