Fecal transfaunation with dietary rice bran-modified human gut microbial consortia confer protection against colon carcinogenesis

This study demonstrated that human stool microbiota from colorectal cancer survivors that consumed rice bran daily elicited protection from chemically-induced colon carcinogenesis after fecal microbiota transplantation (FMT) into germ-free mice. Rice bran driven modifications to human gut microbial communities and the associated metabolite changes represent a novel therapeutic approach to prevent colorectal cancer and has high relevance to precision medicine in high-risk individuals.