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Single-molecule long-read sequencing reveals the chromatin basis of gene expression

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NIAID Data Ecosystem2026-03-10 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA510813
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资源简介:
Chromatin status is highly relevant to gene transcription. We present a new experimental approach MeSMLR-seq (methyltransferase treatment followed by single-molecule long-read sequencing) for long-range mapping of chromatin accessibility and nucleosomes at single DNA molecules, and thus achieve comprehensive-coverage characterization of the corresponding heterogeneity.
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2018-12-19
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