Lampiran Jurnal Formulasi Ondansetron.docx

Inadequate management of these side effects can impact the healing response of cancer patients. Ondansetron is an optimal medication for treating nausea and vomiting side effects, but it falls under the BCS class II drug category. Using sodium starch glycolate (SSG) and pregelatinized starch (PG) can enhance the solubility of ondansetron in body fluids. This research aims to determine the effect of super disintegrants on ondansetron dissolution and to identify the optimal formula for increasing ondansetron dissolution. Ondansetron tablets were prepared using the wet granulation method and divided into nine formulas. The variations in SSG and PG concentrations used were 0%, 1%, 3%, 5%, and 7%. The tablets were evaluated for their physical and chemical quality. The results showed that ondansetron dissolution increased with SSG and pregelatinized starch at 1% and 3%. However, at concentrations of 5% and 7%, ondansetron dissolution decreased. Varying concentrations of SSG and PG produced significant differences in dissolution fraction parameters and dissolution efficiency with p values < 0.05. The optimum formula for enhancing ondansetron dissolution is PG 3%, which achieved a dissolution efficiency value of 79.879% + 0.107.