Advanced Genetic and Molecular Analysis of Solid Tumors

This study is designed to understand the role of immunosuppressive regulatory B cells (Breg) in pancreatic cancer. Breg and conventional B cells (Bcon) from patients are compared by RNA sequencing analysis. Bregs and Bcon were isolated from freshly isolated PBMCs in peripheral blood. These data represent the examination of differentially expressed genes in these two blood-derived B cell subsets from both healthy and pancreatic cancer patients.]]>
Exclusion criteria were that the patients from which samples were taken from were treatment naïve. Inclusion criteria for pancreatic cancer samples were that they were enriched for expression of IL12A and EBI3 by qPCR validation prior to RNA sequencing.]]>