Effect of nitric oxide on the reversal of adriamycin resistance in NCI/ADR-RES tumor cells. Effect of nitric oxide on the reversal of adriamycin resistance in NCI/ADR-RES tumor cells

To understand how nitric oxide is involved in reversal of resistance and investigate mechanisms of Pgp-dependent efflux and genes in involved in drug resistance. Overall design: NCI/ADR-RES cells were treated with Adriamycin, DETNO or combinations of Adriamycin and DETNO for 24 hours.