Crystal structure of the Kelch domain of human KLHL12 with compound 8m

Crystal structure of the Kelch domain of human KLHL12 with compound 8m Descriptor: 2-(4-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-N-(2,4,6-trichlorophenyl)acetamide, Kelch-like protein 12 Authors: Amporndanai, K, Madrigal-Carrillo, E.A, Rietz, T.A, Zhao, B, Fesik, S.W. Deposit date: 2025-09-11 Release date: 2026-04-08 Last modified: 2026-04-22 Method: X-RAY DIFFRACTION (1.308 Å) Cite: Identification of KLHL12 Ligands Using Fragment-Based Methods. J.Med.Chem., 69, 2026人源KLHL12的Kelch结构域（Kelch domain）与化合物8m的晶体结构 配体描述：2-(4-甲基-1H-咪唑并[4,5-c]吡啶-1-基)-N-(2,4,6-三氯苯基)乙酰胺 作者：Amporndanai K、Madrigal-Carrillo E.A、Rietz T.A、Zhao B、Fesik S.W. 提交日期：2025-09-11 发布日期：2026-04-08 最后修改日期：2026-04-22 测试方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.308 Å 引用文献：基于片段筛选法鉴定KLHL12配体，《药物化学杂志》（J.Med.Chem.），第69卷，2026年