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Decoding YAP dependent transcription in the liver [HepG2_RNASeq]

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP365071
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In this study we aimed to address how YAP elicits profound biological changes in murine liver, such as proliferation, regeneration and dedifferentiation. We demonstrated that YAP is a master regulatori of liver functions, that reshapes the enhancer landscape to control transcription of genes involved in metabolism, proliferation and inflammation. Overall design: In total 5 conditions from HEPG2 pSLIKK YAPs127a cells were analyzed in triplicate:not treated (NT) and YAPS127A induced cells for 48h (48h_doxy); control (siCTRL) and two different HNF4a siRNA (siNHF4a_1/2)
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2022-07-26
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