Effect of RADA on Mortality within 24 h.

Mortality data at <24 h following single unilateral intracerebral (ic) inoculation of brain homogenates and RADA. Normal (PrPc) or Scrapie (PrPsc) infected hamster brain homogenates were inoculated alone (−) or with 0.9% w/v RADA (+). Low melt Agarose (0.9% w/v) combined with PrPsc served as an additional control. RADA alone or combined with PrPc brain homogenate resulted in no lethality. Combined RADA with PrPsc resulted in a rapid mortality within 24 h in ∼20% of the animals inoculated. N = number of hamsters inoculated.