Species Distribution and Antifungal Susceptibility of Aspergillus Clinical Isolates: A Multicenter Study in Taiwan, 2016-2020. Aspergillus flavus

This multicenter study investigated the species distribution and antifungal susceptibility of 492 Aspergillus clinical isolates collected during 2016-2020 in Taiwan. They were identified by calmodulin-sequencing and tested for antifungal susceptibility using CLSI 38-A3. Three voriconazole non-wild-type Aspergillus flavus isolates were identified, one (strain no. 2020-C03-025) of which carried an amino acid substitution G441S in Cyp51A. One azole-susceptible A. flavus isolate (strain no. 2020-F03003) carried an amino acid substitution Y319H substitution in Cyp51C.