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DRG2 is required for cell surface localization of PD-L1 in melanoma cells and optimum response to anti-PD-1 immune checkpoint blockade

NIAID Data Ecosystem2026-05-01 收录

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PD-L1定位调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE231974 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-11-06

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基因表达分析

Differential gene expression analysis between Interferon Resistance Score (IRS) high and low tumors in four melanoma cohorts. Related to Figure 2.

Figshare2023-07-05 更新50

Gene expression profiles of melanoma tumor samples from patients treated with checkpoint inhibitors (human). Gene expression profiles of melanoma tumor samples from patients treated with checkpoint inhibitors (human)

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基因表达生物标志物

Tumor samples were obtained from patients with metastatic melanoma before treatment with checkpoint inhibitors. Overall design: melanoma tumor samples from patients treated with checkpoint inhibitors

NIAID Data Ecosystem40

Splicing patterns in SF3B1 mutated uveal melanoma generate shared immunogenic tumor-specific neo-epitopes [scADT-seq]

肿瘤新抗原

黑色素瘤免疫治疗

Purpose: In this study, we show that mutations of the splicing factor SF3B1 in uveal melanoma (UM) generate immunogenic neo-antigens. Thawed PBMC from patient UM1 were stained with PE and APC

NIAID Data Ecosystem30

Supplementary Material: Treatment and Overall Survival Among Anti-PD-1 Exposed Advanced Melanoma Patients with Evidence of Disease Progression

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总生存期分析

Table S1 Patient characteristics by type of index therapy

Taylor & Francis Group2024-05-16 更新40

Whole Exome Sequening of B16F10 melanoma mouse model for ATLAS identification.

肿瘤新抗原

黑色素瘤免疫治疗

The ATLAS bioassay was developed to empirically identify neoantigens by expressing each unique patient-specific tumor mutation individually in E. coli, pulsing autologous dendritic cells in an ordered

NIAID Data Ecosystem30

DRG2 is required for cell surface localization of PD-L1 in melanoma cells and optimum response to anti-PD-1 immune checkpoint blockade

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