Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #1
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Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #1 Descriptor: 1,3-thiazolidin-3-yl[(2S,4S)-4-{4-[2-(trifluoromethyl)quinolin-4-yl]piperazin-1-yl}pyrrolidin-2-yl]methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Akahoshi, F, Kishida, H, Miyaguchi, I, Yoshida, T, Ishii, S. Deposit date: 2011-10-24 Release date: 2012-08-15 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group Bioorg.Med.Chem., 20, 2012
人二肽基肽酶IV（DPP-4）与脯氨酰噻唑烷抑制剂#1复合物的晶体结构
描述符：1,3-噻唑烷-3-基[(2S,4S)-4-{4-[2-(三氟甲基)喹啉-4-基]哌嗪-1-基}吡咯烷-2-基]甲酮、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等
作者：Akahoshi, F、Kishida, H、Miyaguchi, I、Yoshida, T、Ishii, S
存放日期：2011-10-24
发布日期：2012-08-15
最后修改日期：2024-10-09
测试方法：X射线衍射（分辨率2.1 Å）
引用文献：《不含亲电腈基的稠环杂芳基哌嗪取代L-脯氨酰噻唑烷类强效DPP-4抑制剂》，发表于Bioorg.Med.Chem. 20卷，2012年
创建时间：
2011-10-24
