Transcriptomic analysis of healthy donor and Sickle Cell Disease (SCD) hematopoietic stem/progenitor cells

Human hematopoietic stem/progenitor cells (HSPCs) were either collected from bone marrow or mobilized from healthy donors and SCD patients. We performed RNA-seq analysis on RNA extracted from purified CD34+ HSPCs coming from the different sources to compare their gene expression profiles. Overall design: RNA-sequencing of CD34+ cells collected from bone marrow or mobilized from healthy donors and SCD patients.