Women's lifestyle and health - 1991

Oral contraceptives, use of hormone replacement therapy, dietary habits and other lifestyle factors affect the risk for cancer, cardiovascular diseases and other chronic diseases in young women. Starting in 1991, a comprehensive questionnaire was mailed to 96,000 Swedish women aged 29-49 years. Approximately 50,000 completed questionnaires were returned providing detailed information on a wide range of lifestyle factors with a focus on oral contraceptive use, diet, UV light exposure, and reproductive factors. This study is strictly coordinated with a similar study among 60,000 young women in Norway; apart from the dietary component, the questionnaires are identical and joint analyses have been conducted. In 2003, a second questionnaire was sent to all women to update information on lifestyle, and hormonal factors as well as to assess mental health. Currently analysis is ongoing for several lifestyle factors and cancers of the breast, ovarium, endometrial, colorectal, skin, skin melanoma, lymphomas, as well as cardiovascular outcomes (myocardial infarction, haemorragic and ischaemic stroke), psychiatric diseases, sleeping disorders and overall mortality. Several analyses have been performed during the last years on different exposures, such as oral contraceptives, BMI, changes in body size and shape, UV radiation exposure, alcohol consumption, smoking, and risk of different cancer sites and overall mortality. Purpose: The overall aim of Women's lifestyle and health cohort is to examine lifestyle factors and health outcomes such as cancer, cardiovascular diseases and some chronic diseases. The baseline questionnaire was mailed to 96,000 Swedish women aged 29-49 years, in 1991. The questionnaire was answered by 49,259 women.口服避孕药（Oral Contraceptives）的使用、激素替代疗法（Hormone Replacement Therapy）的应用、饮食习惯及其他生活方式因素，均可影响年轻女性罹患癌症、心血管疾病及其他慢性疾病的风险。自1991年起，研究团队向96000名年龄介于29~49岁的瑞典女性邮寄了综合性调查问卷。最终回收约50000份完整问卷，其中涵盖了多维度生活方式因素的详细信息，重点关注口服避孕药使用情况、饮食、紫外线暴露及生殖相关因素。本研究与挪威针对60000名年轻女性开展的同类研究严格协同：除饮食模块外，两份问卷完全一致，且已完成联合分析。 2003年，研究团队向所有受试者寄送了第二份问卷，用于更新其生活方式、激素相关因素的信息，并评估心理健康状况。目前，多项分析正在进行中，涉及多种生活方式因素与乳腺癌、卵巢癌、子宫内膜癌、结直肠癌、皮肤癌、皮肤黑色素瘤（Skin Melanoma）、淋巴瘤的关联，以及心血管结局（心肌梗死（Myocardial Infarction）、出血性脑卒中（Haemorrhagic Stroke）、缺血性脑卒中（Ischaemic Stroke））、精神疾病（Psychiatric Diseases）、睡眠障碍（Sleeping Disorders）与全因死亡率（Overall Mortality）的关联。 近年来，研究团队已针对多种暴露因素开展了多项分析，包括口服避孕药使用、体质量指数（Body Mass Index, BMI）、体型变化、紫外线辐射暴露、饮酒行为、吸烟情况，以及不同部位癌症风险与全因死亡率的关联。 研究目标： 女性生活方式与健康队列研究（Women's Lifestyle and Health Cohort）的总体目标为探究生活方式因素与癌症、心血管疾病及部分慢性疾病等健康结局的关联。 1991年，研究团队向96000名29~49岁的瑞典女性邮寄了基线调查问卷，最终共有49259名女性完成并返回了问卷。