Antidepressants treatment, but not treatment with other psychotropic drugs, increased the FGF-2 mRNA expression in cortical astrocyte cultures.

Cells were treated with 25 µM of amitriptyline, clomipramine, fluvoxamine, duloxetine, diazepam, haloperidol, trihexyphenidyl or diphenhydramine for 24 h, and the FGF-2 mRNA expression was analyzed by real time PCR. The values are shown as the ratio of FGF-2 mRNA to GAPDH mRNA. The data are expressed as the means ± S.E.M. (% of basal) *ppt-test; n = 3–4).