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Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA776265
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Bin2 mutated frequently in diverse human cancers including ovarian cancer. Interestingly, we primarily showed that expression of these conserved mutants in diverse normal cell lines could up-regulate mTOR activity. Thus, it might be a novel mTOR-involved gene essential for not only tumorigenesis but also fertility.
创建时间:
2021-10-29
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