Photoinduced Isomerization of 23-Oxosapogenins: Conformational Analysis and Spectroscopic Characterization of 22-Isosapogenins
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https://figshare.com/articles/dataset/Photoinduced_Isomerization_of_23_Oxosapogenins_Conformational_Analysis_and_Spectroscopic_Characterization_of_22_Isosapogenins/2458066
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资源简介：
The first synthesis of 22-isospirostane derivatives is
described.
They were obtained by photochemical isomerization of 23-oxosapogenins.
The structure of 23-oxo-22-isotigogenin acetate (12)
was proved by a single crystal X-ray diffraction, while structures
of 23-oxo-22-isodiosgenin acetate (13) and 23-oxo-22-isosarsasapogenin
acetate (14) were elucidated by spectroscopic methods.
22-Isodiosgenin acetate (17) was obtained by NaBH4 reduction of the 23-oxo derivative 13 followed
by the two-step Barton–McCombie deoxygenation procedure. Conformational
analysis of 22-iso compounds was carried out with CD and NMR, as well
as DFT calculations.
创建时间：
2016-02-20
