Increased VLDL cholesterol and triglycerides in LDLr KO mice receiving ORP8 KO bone marrow.

Blood was isolated from LDLr KO mice after transplantation with ORP8 KO bone marrow (BM) or Wild Type (WT) BM. Lipoproteins were fractioned by size using FPLC and cholesterol and triglyceride contents were measured in each fraction. A) 17 weeks after transplantation and after 9 weeks of WTD feeding ORP8 KO BM recipients exhibit increased VLDL cholesterol (* P<0.05) B) Similarly, an increase in triglycerides in the VLDL fraction in blood of ORP8 KO BM recipients on WTD was found (* P<0.05). Significance was determined by Student t-test. N = 7, data are expressed as mean ±SEM.