File S1 - Missense Variants of Uncertain Significance (VUS) Altering the Phosphorylation Patterns of BRCA1 and BRCA2

Table S1, Summary of the BRCA1 phosphorylation motifs studied. A list of all BRCA1 phosphorylation sites studied. Bolded phosphorylation site represents in vivo phosphorylated residues. *STK6 score fell below the cut-off value of 5 but since it has previously been shown experimentally (Ouchi, et al., 2004) it is included. ** S405 and S1286 were excluded from the study due to wildtype predictions below the score of 5. Table S2, Summary of the BRCA2 phosphorylation motifs studied. A list of all BRCA2 phosphorylation sites studied. Bolded phosphorylation site represents in vivo phosphorylated residues. * S206, S384, Y3009 were excluded from the study due to wildtype predictions below the score of 5. Table S3, BRCA1 and BRCA2 variants identified in this study to affect biologically characterized phosphorylation sites and were also previously reported in other publications (retrieved from the Leiden Open Variation Database 2.0 (Build 35)). Table S4, BRCA1 and BRCA2 variants identified in this study to affect biologically uncharacterized phosphorylation sites and were also previously reported in other publications (retrieved from the Leiden Open Variation Database 2.0 (Build 35)). (DOCX)