Frequency of HPE spectrum defects in ethanol-treated 129S6.<i>Cdon<sup>−/−</sup></i> mice at different stages of analysis.
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*p<0.05, when comparing ethanol-treated Cdon−/− embryos with saline and ethanol-treated Cdon+/+ embryos and saline-treated Cdon−/− embryos. **p>0.05, due to the relatively low n (4) for this analysis and the partial penetrance of the phenotype. However, in our experience, lobar HPE and defective palatogenesis are not observed in either Cdon+/+ or Cdon−/− embryos on the 129S6 background [27], [28]. 1Agnathia spectrum phenotypes include complete lack of mandible (1/14) and fused, shortened mandibular bone (2/14).
创建时间:
2012-10-11



