Expression profiling of Atm deficient murine thymic lymphoma

To find genes deregulated in the pathogenisis of T-cells in Atm deficient mice, we performed expression profiling of Atm deficient thymic lymphomas, wildtype thymi and Atm deficient thymi without macroscopic enlargement, representing an intermediate stage in the process of tumorigenisis. Keywords: genetic modification, disease state analysis To evaluate differential gene expression of Atm deficient thymic lymphoma we performed microarray based expression profiling of 8 Atm deficient thymic lymphomas, 6 wildtype thymi, 1 thymus of an Atm heterozygous mouse and 18 thymi of Atm deficient mice without macroscopic enlargement.