Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci

Lifespan is an integrative phenotype whose genetic architecture is likely
to highlight multiple processes with high impact on health and aging.
Here, we conduct a genetic meta-analysis of longevity in Diversity Outbred
(DO) mice that includes 2,444 animals from three independently conducted
lifespan studies. We identify six loci that contribute significantly to
lifespan independently of diet and drug treatment, one of which also
influences lifespan in a sex-dependent manner, as well as an additional
locus with a diet-specific effect on lifespan. Collectively, these loci
explain over half of the estimated heritable variation in lifespan across
these studies and provide insight into the genetic architecture of
lifespan in DO mice.