Interferon response to HSV-1 virion binding.

Note. *p<0.05. Binding by ΔgB and ΔgH virions up-regulated the expression of IFN-α whereas ΔgB and ΔgD virions were able to stimulate an increase in IFN-β. Infection with wild-type HSV-1 at an MOI of 0.01 was insufficient to cause similar increases in interferon expression. Interferon-stimulated genes were not up-regulated above the two-fold threshold by binding of any of the entry-defective HSV-1 mutants. Wild-type infection at a low MOI was also insufficient to cause in increase in ISG transcripts when compared to mock-infected cells.