Complement factor D in complex with the inhibitor (2S,4S)-4-Amino-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide]

Complement factor D in complex with the inhibitor (2S,4S)-4-Amino-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide] Descriptor: (2~{S},4~{S})-~{N}1-(1-aminocarbonylindol-3-yl)-4-azanyl-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide, Complement factor D Authors: Mac Sweeney, A, Ostermann, N. Deposit date: 2017-03-01 Release date: 2017-06-28 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017

补体因子D（Complement factor D）与抑制剂(2S,4S)-4-氨基吡咯烷-1,2-二羧酸1-[(1-氨基甲酰基-1H-吲哚-3-基)-酰胺]2-[(3-三氟甲氧基苯基)-酰胺]形成复合物。描述符：(2S,4S)-N¹-(1-氨基甲酰基吲哚-3-基)-4-氨基-N²-[3-(三氟甲氧基)苯基]吡咯烷-1,2-二甲酰胺。该研究对象为补体因子D，作者为Mac Sweeney, A.、Ostermann, N.。沉积日期：2017-03-01，发布日期：2017-06-28，最后修改日期：2026-03-04。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.75埃（Å）。引用文献：《可在体内实现补体旁路通路抑制的高活性高选择性小分子可逆因子D抑制剂的发现》，《J. Med. Chem.》，2017年，第60卷。