Cell features for "Datasets for "Predicting microsatellite instabilitiy from histology images with a three-level hierarchical graph fusion model""

This repository contains features and corresponding coordinates of cells extracted from 430 and 326 histologic images from patients with colorectal and gastric cancers from the TCGA cohort (original whole section SVS images are freely available at https://portal.gdc.cancer.gov/). All images in this library are from formalin-fixed paraffin-embedded (FFPE) diagnostic sections (“DX” on the GDC Data Portal). This blog explains this in detail: http://www.andrewjanowczyk.com/download-tcga-digital-pathology-images-ffpe/

Preprocessing.

All SVS slices were pre-processed as follows.

According to “Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer” these histology images were categorized into “MSS” (microsatellite stable) or “MSIMUT” (microsatellite unstable or highly mutated) and corresponded to the article dividing the training and test sets.

The features of all cells were extracted by Hovernet and Transnuseg at 40x objective magnification for extraction masking and further feature extraction