Additional file 1 of Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Additional file 1: Table S1. Cohort descriptives and measurements. Table S2. List of GWAS summary statistics used and features of the studies. Table S3. Results of Hyprcoloc colocalization. Table S4. Results of SuSiE colocalization. Table S5. SNP correlation matrix used to construct network. Table S6. Variant-trait z-scores for clusters. Table S7. SNPs used to construct PGIs. Table S8. Associations between PGIs and metabolic outcomes. Table S9. Associations between PGIs and metabolic outcomes controlling for medication usage. Table S10. Associations of individuals in top and bottom deciles to metabolic outcomes. Table S11. Results of Mendelian randomization between BMI/VAT and clusters. Table S12. Results of Steiger z test. Table S13. Associations of PGIs in GENR pediatric cohort. Table S14. Associations of PGIs and clinical outcomes. Table S15. Associations of PGIs and clinical outcomes adjusting for medication. Table S16. Associations between PGIs and metabolic outcomes for clusters with fewer than 4 variants. Table S17. Associations between PGIs and metabolic outcomes for Kim et al. clusters.