Total RNA-seq of DNMT3a/3b induced double knockouts in mouse embryonic fibroblasts
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https://www.ncbi.nlm.nih.gov/sra/SRP441239
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资源简介：
To test whether DNMT3A/3B are mechanistically responsible for the probabilistic gain of methylation at intermediately methylated CpG sites, we generated four MEF lines (A, B, C, and D) from sibling E13.5 Dnmt3aflox/flox3bflox/flox mouse embryos and used recombinant TAT-CRE protein to induce the double knockout (DKO) in vitro. We subsequently performed RNA-seq with four DKO and four matched control cell lines.
创建时间：
2023-06-30
