TrkA phosphorylates PLCG1

Mutational analysis of tyrosine residues, highly conserved in the cytoplasmic domain of all Trk receptors, reveal that the activation of PLC-gamma is necessary to mobilize Ca2+ from intracellular stores, the key mechanism for regulated NT secretion.

对存在于所有Trk受体胞浆域中高度保守的酪氨酸残基进行突变分析，揭示PLC-γ的激活是动员细胞内储存的Ca2+的必要条件，该机制是调节性神经肽分泌的关键途径。