Summary statistics for publication entitled 'Associations between sickle-haemoglobin and mutations in Plasmodium falciparum CLAG and FIKK gene families revealed by meta-analysis of 6,289 African samples'
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This contains two sets of association test summary statistics associated with this preprint:1. Tests for the P. falciparum genetic correlates of malaria disease severity using parasite genetic data from a set of severe and mild cases collected in The Gambia (1988-90) known as the GAMCC dataset. 2. A meta-analysis of associations between human HbS genotype and P. falcaiprum genome-wide genetic variation within 6,289 samples from The Gambia, Kenya, Ghana and Mali. These include severe and mild cases in the GAMCC dataset, the MalariaGEN CP1 dataset of severe cases from The Gambia and Kenya (doi: https://doi.org/10.1038/s41586-021-04288-3), a subset of the mild infections from Ghana in the MalariaGEN Pf7 dataset (https://www.biorxiv.org/content/10.1101/2023.09.14.557461v1.full) and a set of RNA-seq data from mild cases in wild-type and sickle trait carriers collected in Mali (10.1128/mSphere.00755-21).In addition, we have included tab separated versions of supplementary tables (supp_table1-4.tsv) as well as a sample per line version of supp_table1 containing parasite genotypes at loci of interest, which may be of use.



