TDR Targets

TDR Targets integrates chemical and genomic information and allows users to prioritize targets and compounds to develop and repurpose new drugs and chemical tools for human pathogens. The TDR Target Project was started in 2005 after a call for applications was launched by TDR (Special Programme for Research and Training in Tropical Diseases). As a result, the TDR Targets Database was established to help develop a portfolio of candidate drug targets for 5 major human pathogens. This then became a resource for prioritizing targets for neglected tropical diseases. TDR Targets is led and run by the Trypanosomatics group at IIB-UNSAM (Argentina, https://trypanosomatics.org) with help with external collaborators worldwide.

TDR靶点数据库（TDR Targets）整合化学与基因组学信息，可支持用户对靶点与化合物进行优先级筛选，以开发新型药物、开展药物重定位研究，并为人类病原体研发专用化学工具。TDR靶点项目（TDR Target Project）于2005年启动，彼时热带疾病研究与培训特别规划署（Special Programme for Research and Training in Tropical Diseases）发布了项目申报征集。借此，TDR靶点数据库（TDR Targets Database）正式建成，旨在为5种主要人类病原体构建候选药物靶点库。此后该平台逐渐发展为针对被忽视热带病的靶点优先级筛选资源库。TDR靶点数据库由阿根廷IIB-UNSAM的锥虫学研究组（Trypanosomatics group）主导运营，并得到了全球各地外部合作者的支持，其官方网址为https://trypanosomatics.org。

搜集汇总

背景与挑战

背景概述

TDR Targets 是一个化学基因组数据库，专注于整合化学和基因组数据，以优先排序药物靶点和化合物，从而开发和重新利用针对人类病原体（特别是被忽视热带病）的新药和化学工具。该项目由阿根廷IIB-UNSAM的Trypanosomatics团队主导，自2005年启动，旨在为多种病原体构建候选药物靶点组合。