Codon-Permissive Residues at the hACE2 Interface: Position-Resolved Codon Usage Across 240 Million SARS-CoV-2 Genomes (2020 - 2025)

This dataset provides the first position-resolved codon usage analysis of the SARS-CoV-2 Spike protein across 240 million global genomes (2020 - 2025). Focusing on residues within 2 - 5 Angstrom of the hACE2 interface (PDB 6M0J), we quantify codon frequency, RSCU, and Codon-Permissiveness Score (CPS) for each residue, enabling data-driven discovery of novel immune escape hotspots without reliance on prior experimental annotation. Data derived from public repositories (GISAID, NCBI) via GVATLAS alignment and processed using a RAM-safe, checkpoint-resumable pipelines. Intended for use in manuscript.