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Azamerone, a Terpenoid Phthalazinone from a Marine-Derived Bacterium Related to the Genus <i>Streptomyces</i> (Actinomycetales)

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NIAID Data Ecosystem2026-03-06 收录
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A novel meroterpenoid, azamerone, was isolated from the saline culture of a new marine-derived bacterium related to the genus Streptomyces. Azamerone is composed of an unprecedented chloropyranophthalazinone core with a 3-chloro-6-hydroxy-2,2,6-trimethylcyclohexylmethyl side chain. The structure was rigorously determined by NMR spectroscopy and X-ray crystallography. A possible biosynthetic origin of this unusual ring system is proposed.

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2016-03-01
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