miRNA data-ONCOTOXICOLOGICAL PROGRAMMING BY THE MATERNAL EXPOSURE TO A PHTHALATE MIXTURE: miRNAS and mRNA EXPRESSION PROFILE INTEGRATION.. Rattus norvegicus

The incidence of chronic diseases such as diabetes and obesity, as well as genetic diseases such as cancer, has increased in recent decades due to several socioeconomic and environmental factors that seem to interfere in the development, incidence and prognosis of these diseases. Regarding cancer, the temporal factor distances up to 50-60 years the stages of initiation and tumor progression, and thus the manifestation of cancer can occur many years after contact with a possible etiological factor. Thus, environmental factors that interfere with intrauterine development and promote transient or permanent morphofunctional, genetic and epigenetic changes, including those that can be transmitted to the offspring. The literature has shown that some toxic substances have the capacity to increase susceptibility to cancer, creating a scientific perspective of great interest to our group. Phthalates represent a group of substances used in industry and are found in different concentrations in the urine and plasma of humans. Thus, the objective of this study will be to investigate whether gestational and lactational exposure to a phthalate mixture is capable of altering the expression of mRNAs and miRNAs in the F1 and F2 generations, and to verify if these alterations are related to targets involved in prostate oncogenesis.