Data from: Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia

Background: There is strong association of Alzheimer's disease (AD)
pathology with gait disorder and falls in older adults without dementia.
The goal of the study was to examine the prevalence and severity of AD
pathology in older adults without dementia who fall and sustain hip
fracture. Methods: Cerebrospinal fluid (CSF) was obtained from 168 hip
fracture patients. CSF Aβ42/40 ratio, p-tau, and t-tau measures were
dichotomized into normal vs. abnormal, and categorized according to the
A/T/N classification. Results: Among the hip fracture patients, 88.6% of
the cognitively normal (Clinical Dementia Rating-CDR 0; n=70) and 98.8%
with mild cognitive impairment (CDR 0.5; n=81) fell in the abnormal
biomarker categories by the A/T/N classification. Conclusions: A large
proportion of older hip fracture patients have CSF evidence of AD
pathology. Preoperative determination of AD biomarkers may play a crucial
role in identifying persons without dementia who have underlying AD
pathology in perioperative settings.